‘Master key’ to unlock new treatments for autoimmune disorders discovered

ScienceDaily (Sep. 29, 2011) — Imagine a single drug that would treat most, if not all, autoimmune disorders, such as asthma, inflammatory bowel disease, and Lupus. That might not be so hard to do thanks to a team of researchers who have discovered a molecule normally used by the body to prevent unnecessary immune reactions. This molecule, pronounced “alpha v beta 6,” normally keeps our immune systems from overreacting when food passes through our bodies, and it may be the key that unlocks entirely new set of treatments for autoimmune disorders.

This discovery was recently published in research report appearing the Journal of Leukocyte Biology.

“Currently we do not have special methods to radically treat most immune diseases; all we can do is to temporarily inhibit the clinical symptoms for those diseases,” said Ping-Chang Yang, a researcher involved in the work from the Department of Pathology and Molecular Medicine at McMaster University in Ontario, Canada. “Our findings have the potential to repair the compromised immune tolerant system so as to lead the body immune system to ‘correct’ the ongoing pathological conditions by itself.”

Scientists made this discovery in mice when they noticed that their intestines secreted alphavbeta6, when absorbing food. Alphavbeta6, together with the absorbed food, induced the body to produce immune tolerant cells, which ensured that the food did not cause an excessive immune reaction. Researchers then generated alphavbeta6 using cultured intestinal cells and found that both could be used to generate the immune tolerant cells needed to reduce or eliminate out-of-control immune reactions.

“Development of new treatments and cures for diseases is usually a long process involving a series of incremental steps taken from the laboratory all the way through to the patient’s bedside,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. “Occasionally, however, scientists make large leaps forward instead. While considerable work remains to determine whether or not this discovery will directly translate into new therapies, the alphavbeta6 discovery reported by these scientists is exciting, if not stunning.”

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS.


Journal Reference:

  1. X. Chen, C.-H. Song, B.-S. Feng, T.-L. Li, P. Li, P.-Y. Zheng, X.-M. Chen, Z. Xing, P.-C. Yang. Intestinal epithelial cell-derived integrin   6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response. Journal of Leukocyte Biology, 2011; 90 (4): 751 DOI: 10.1189/jlb.1210696

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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